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Gary Ruvkun
American geneticist (born )
Gary Bruce Ruvkun (born March 26, ) is an American molecular biologist and Nobel laureate at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston.[3]
Ruvkun discovered the mechanism by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7, and that it is conserved across animal phylogeny, including in humans.
These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and the mechanism of that regulation. Ruvkun also discovered many features of insulin-like signaling in the regulation of aging and metabolism.
He was elected a Member of the American Philosophical Society in Ruvkun was awarded the Nobel Prize in Physiology or Medicine for the discovery of microRNA and its role in post-transcripti
